- Sic1 Mutants
- sic1∆
- sic1∆ cdh1∆
- sic1∆ cdh1∆ GALL-CDC20
- sic1∆ cdc6∆2-49
- sic1∆ cdc6∆2-49 cdh1∆
- sic1∆ cdc6∆2-49 cdh1∆ GALL-CDC20
- GAL-CLB2 sic1∆
- GAL-CLB5 sic1∆
- CLB5-db∆ sic1∆
- APC-A sic1∆
- APC-A sic1∆ cdc6∆2-49
- cdc14-ts sic1∆
- cln1∆ cln2∆ sic1∆
- cln3∆ bck2∆ sic1∆
- cln1∆ cln2∆ cln3∆ sic1∆
- swi5∆
- swi5∆ GAL-CLB2
- swi5∆ cdh1∆
- swi5∆ cdh1∆ GAL-SIC1
- GAL-SIC1
- GAL-SIC1-db∆
- GAL-SIC1 cln1∆ cln2∆
- GAL-SIC1 GAL-CLN2 cln1∆ cln2∆
- GAL-SIC1 cln1∆ cln2∆ cdh1∆
- GAL-SIC1 GAL-CLN2 cln1∆ cln2∆ cdh1∆
- CLB2-db∆ multicopy SIC1
- CLB2-db∆ GAL-SIC1
- cdc14-ts GAL-SIC1
- cdc14ts then GAL-SIC1
- APC-A cdh1∆ GAL-SIC1
- APC-A cdh1∆ multi-copy SIC1
GAL-CLB5 sic1∆
debug: ,
test user =
test db =
Simulation:
Change of parameters: ksb5'=0.012, ksc1'=ksc1"=0, MDT=150.
Arrest: It dies after the first cycle, Ori not relicensed.
Experiments:
Jacobson, M.D., Gray, S., Yuste-Rojas, M. and Cross, F.R. (2000). Testing cyclin specificity in the exit from mitosis. Mol. Cell. Biol. 20:4483-4493.
[Abstract] [Article]
[Abstract] [Article]
Experimental results: Lethal, data not shown.
Comments: It can exit the first mitosis but [ORI] (grey line) is not relicensed, due to high Clb5 kinase activity in G1.
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